Heterocycles from alkylidenecyclopropanes

A Brandi, S Cicchi, FM Cordero, A Goti - Chemical reviews, 2003 - ACS Publications
Heterocyclic compounds, which represent almost two-thirds of all the known organic
compounds, include some of the most significant for human beings. It is not surprising …

Microbial glucoamylases: characteristics and applications

P Kumar, T Satyanarayana - Critical reviews in biotechnology, 2009 - Taylor & Francis
Glucoamylase is one of the oldest and widely used biocatalysts in food industry. The major
application of glucoamylase is the saccharification of partially processed starch/dextrin to …

Optically active isoxazolidines via asymmetric cycloaddition reactions of nitrones with alkenes: applications in organic synthesis

M Frederickson - Tetrahedron, 1997 - Elsevier
Isoxazolidines, the products of 1, 3-dipolar cycloaddition reactionst-s between nitrones and
alkenes, are saturated, five membered heterocycles containing adjacent nitrogen and …

Stereocontrolled cyclic nitrone cycloaddition strategy for the synthesis of pyrrolizidine and indolizidine alkaloids

A Brandi, F Cardona, S Cicchi… - … –A European Journal, 2009 - Wiley Online Library
The synthesis of polyhydroxylated indolizidines and pyrrolizidines belonging to the class of
iminosugars, endowed with a vast and assorted biological activity, can be achieved in a …

C-glycosides and aza-C-glycosides as potential glycosidase and glycosyltransferase inhibitors

W Zou - Current topics in medicinal chemistry, 2005 - ingentaconnect.com
Glycosylation as one of most important post-translational modification of gene products is
often critical to specific cellular biological functions. Since elevated glycoprocessing enzyme …

Synthetic methods for the stereoisomers of swainsonine and its analogues

A El Nemr - Tetrahedron, 2000 - Elsevier
The (1S, 2R, 8R, 8aR)-1, 2, 8-trihydroxyindolizidine,(2)-swainsonine (1), which was first
isolated from the fungus Rhizoctonia leguminicola1 and later found in the Australian plant …

Simple indolizidine and quinolizidine alkaloids

JP Michael - The alkaloids: Chemistry and biology, 2016 - Elsevier
This review of simple indolizidine and quinolizidine alkaloids (ie, those in which the parent
bicyclic systems are in general not embedded in polycyclic arrays) is an update of the …

Enantiopure cyclic nitrones: A useful class of building blocks for asymmetric syntheses

J Revuelta, S Cicchi, A Goti, A Brandi - Synthesis, 2007 - thieme-connect.com
The synthesis of enantiopure cyclic nitrones has become a frequently addressed topic in
discussions of their usefulness in the production of natural products and biologically active …

Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes

X Ferhati, C Matassini, MG Fabbrini, A Goti… - Bioorganic …, 2019 - Elsevier
The diffusion of type 2 diabetes (T2D) throughout the world represents one of the most
important health problems of this century. Patients suffering from this disease can currently …

Highly diastereoselective additions to polyhydroxylated pyrrolidine cyclic imines: ready elaboration of aza‐sugar scaffolds to create diverse carbohydrate‐processing …

TM Chapman, S Courtney, P Hay… - Chemistry–A European …, 2003 - Wiley Online Library
Representative diastereomeric, erythritol and threitol polyhydroxylated pyrrolidine imine
scaffolds have been rapidly elaborated to diversely functionalized aza‐sugars through …