Platelets play a major role in primary hemostasis and thrombus formation. After vascular
injury, platelets adhere to injured site and rapidly change their shape that switches the …

Sickle cell disease (SCD), considered the most common monogenic disease worldwide, is a
severe hemoglobin disorder. Although the genetic and molecular bases have long been …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

A key inflammatory mechanism recently identified in platelets involves the Nod-like receptor
nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) and Bruton …

The genetic and molecular basis of sickle cell disease (SCD) has long been characterized
but the pathophysiological basis has not been entirely defined. How a red cell hemolytic …

Platelets play a critical role at the interphase of thrombosis and inflammation, key features in
haemolysis‐associated disorders. Exercising this role requires expression of pattern …

Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …

Progress in the care of sickle cell disease (SCD) has been hampered by the extreme
complexity of the SCD phenotype despite its monogenic inheritance. While epidemiological …

Children with sickle cell anemia (SCA) suffer from a chronic state of inflammation due to
repeated tissue insult from sickling red blood cells. The clinical consequences are severe …

Background The clinical presentation of acute chest syndrome is similar whether due to
infectious or non‐infectious causes, thus antibiotics are usually prescribed to treat all …