Measuring indirect radiation-induced perfusion change in fed vasculature using dynamic contrast CT

AE Wuschner, MJ Flakus, EM Wallat… - Journal of personalized …, 2022 - mdpi.com
Recent functional lung imaging studies have presented evidence of an “indirect effect” on
perfusion damage, where regions that are unirradiated or lowly irradiated but that are …

CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion

AE Wuschner, MJ Flakus, EM Wallat… - Frontiers in …, 2022 - frontiersin.org
Vessel segmentation in the lung is an ongoing challenge. While many methods have been
able to successfully identify vessels in normal, healthy, lungs, these methods struggle in the …

Radiation-induced airway changes and downstream ventilation decline in a swine model

EM Wallat, AE Wuschner, MJ Flakus… - Biomedical physics …, 2021 - iopscience.iop.org
Purpose. To investigate indirect radiation-induced changes in airways as precursors to
atelectasis post radiation therapy (RT). Methods. Three Wisconsin Miniature Swine (WMS …

Metrics of dose to highly ventilated lung are predictive of radiation-induced pneumonitis in lung cancer patients

MJ Flakus, SP Kent, EM Wallat, AE Wuschner… - Radiotherapy and …, 2023 - Elsevier
Purpose To identify metrics of radiation dose delivered to highly ventilated lung that are
predictive of radiation-induced pneumonitis. Methods and Materials A cohort of 90 patients …

Combining serial and parallel functionality in functional lung avoidance radiation therapy

EM Vicente, A Modiri, J Kipritidis, KC Yu, K Sun… - International Journal of …, 2022 - Elsevier
Purpose Functional lung avoidance (FLA) radiation therapy (RT) aims to minimize post-RT
pulmonary toxicity by preferentially avoiding dose to high-functioning lung (HFL) regions. A …

[HTML][HTML] Incorporating functional lung imaging (FLI) into radiation therapy planning in patients with lung cancer: A systematic review and meta-analysis

J Midroni, R Salunkhe, Z Liu, R Chow, G Boldt… - International Journal of …, 2024 - Elsevier
Purpose To provide an understanding of current FLI techniques, and their potential to
improve dosimetry and outcomes for lung cancer patients receiving radiation therapy (RT) …

Late central airway toxicity after high-dose radiotherapy: clinical outcomes and a proposed bronchoscopic classification

JE van Hoorn, M Dahele, JMA Daniels - Cancers, 2021 - mdpi.com
Simple Summary High-dose radiotherapy is frequently used to treat lung cancer, however, it
can cause serious central airway toxicity. Although radiation toxicity of the lung parenchyma …

Virtual bronchoscopy-guided lung SAbR: dosimetric implications of using AAA versus Acuros XB to calculate dose in airways

P Kinkopf, A Modiri, KC Yu, Y Yan… - Biomedical physics …, 2021 - iopscience.iop.org
In previous works, we showed that incorporating individual airways as organs-at-risk (OARs)
in the treatment of lung stereotactic ablative radiotherapy (SAbR) patients potentially …

Integrating local and distant radiation‐induced lung injury: Development and validation of a predictive model for ventilation loss

EM Vicente, N Grande Gutierrez, JM Oakes… - Medical … - Wiley Online Library
Background Investigations on radiation‐induced lung injury (RILI) have predominantly
focused on local effects, primarily those associated with radiation damage to lung …

[图书][B] Advancing CT-Ventilation Biomarker Utility in Lung Functional Avoidance Radiation Therapy

MJ Flakus - 2023 - search.proquest.com
Lung functional avoidance radiation therapy is a technique that has potential to mitigate
radiation-induced lung injuries. In functional avoidance, treatment plans are optimized to …