Understanding the diversity of membrane lipid composition
T Harayama, H Riezman - Nature reviews Molecular cell biology, 2018 - nature.com
Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine
TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER)
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …
ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its
recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases) …
recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases) …
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients,
including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified …
including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified …
NPC1-mTORC1 signaling couples cholesterol sensing to organelle homeostasis and is a targetable pathway in Niemann-Pick type C
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
Lipid-sorting specificity encoded in K-Ras membrane anchor regulates signal output
K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that
comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative …
comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative …
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol
H Kemmoku, K Takahashi, K Mukai, T Mori… - Nature …, 2024 - nature.com
Stimulator of interferon genes (STING) is critical for the type I interferon response to
pathogen-or self-derived DNA in the cytosol. STING may function as a scaffold to activate …
pathogen-or self-derived DNA in the cytosol. STING may function as a scaffold to activate …
Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol
SL Liu, R Sheng, JH Jung, L Wang, E Stec… - Nature chemical …, 2017 - nature.com
Controlled distribution of lipids across various cell membranes is crucial for cell homeostasis
and regulation. We developed an imaging method that allows simultaneous in situ …
and regulation. We developed an imaging method that allows simultaneous in situ …
ORP1L mediated PI (4) P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division
Mitochondrial division is not an autonomous event but involves multiple organelles,
including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the …
including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the …