Cloning and expression heterologous alanine dehydrogenase genes: Investigation of reductive amination potential of L-alanine dehydrogenases for green synthesis …
Unnatural amino acids (UAAs) offer significant promise in a wide range of applications,
including drug discovery, the custom design of peptides and proteins, and their utility and …
including drug discovery, the custom design of peptides and proteins, and their utility and …
Application of reductive amination by heterologously expressed Thermomicrobium roseum L-alanine dehydrogenase to synthesize L-alanine derivatives
H Dedeakayoğulları, J Valjakka, O Turunen… - Enzyme and Microbial …, 2023 - Elsevier
Unnatural amino acids are unique building blocks in modern medicinal chemistry as they
contain an amino and a carboxylic acid functional group, and a variable side chain …
contain an amino and a carboxylic acid functional group, and a variable side chain …
Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small‐molecule antibiotics
A Van Wieren, JD Durrant… - Drug Development …, 2023 - Wiley Online Library
Given the ever‐present threat of antibacterial resistance, there is an urgent need to identify
new antibacterial drugs and targets. One such target is alanine racemase (Alr), an enzyme …
new antibacterial drugs and targets. One such target is alanine racemase (Alr), an enzyme …
[PDF][PDF] Enzymatic and Structural Characterization of Alanine Racemase from Enterococcus faecium by Kinetic and Computational Studies.
A Van Wieren, E Bouchard… - American Journal of …, 2021 - ajuronline.org
The surge in vancomycin-resistant enterococci (VRE) strains poses a serious threat to public
and clinical health. VRE strains are the leading cause of multi-drug resistant enterococcal …
and clinical health. VRE strains are the leading cause of multi-drug resistant enterococcal …