ABC transporters catalyze transport reactions, such as the high-affinity uptake of
micronutrients into bacteria and the export of cytotoxic compounds from mammalian cells …

Paclitaxel (Taxol®) is a member of the taxane class of anticancer drugs and one of the most
common chemotherapeutic agents used against many forms of cancer. Paclitaxel is a …

Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug
resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one of the best studied …

Abstract P-glycoprotein (P-gp) is a member of ATP-binding cassette (ABC) superfamily
which extrudes chemotherapeutic agents out of the cell. Suppression of this efflux activity …

The ATP-binding cassette transporters (ABC transporters) have been intensely studied over
the past 50 years for their involvement in the multidrug resistance (MDR) phenotype …

ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out
essential substrate transport reactions across cell membranes. Their transmembrane …

The complex orchestration of gene expression that mediates the transition of epithelial cells
into mesenchymal cells is implicated in cancer development and metastasis. As the primary …

Multidrug resistance (MDR) proteins related to the ATP-binding cassette family are found in
a very wide range of human tumors and result in therapeutic failure. The overexpression of …

Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer
from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the …

Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-
negative bacteria, some of these pumps form complex tripartite assemblies in association …