Substantial advances have been made recently in the pathobiology of pituitary tumors.
Similar to many other endocrine tumors, over the last few years we have recognized the role …

Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations
showing different morphological features, immunophenotype, molecular background …

Neuroendocrine neoplasia is described in almost every tissue, either in the pure endocrine
organs, the nerve structures or in the so-called diffuse neuroendocrine system. The current …

Growth hormone (GH)-secreting pituitary tumours represent the most genetically determined
pituitary tumour type. This is true both for germline and somatic mutations. Germline …

Abstract The WHO Classification of Endocrine Tumours designates pituitary neoplasms as
adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) …

Objective To profile clinically non‐aggressive and aggressive pituitary adenomas
(PAs)/pituitary neuroendocrine tumours (PitNETs) and pituitary carcinomas for somatic …

Pituitary adenomas are rare in children and young people under the age of 19 (hereafter
referred to as CYP) but they pose some different diagnostic and management challenges in …

The majority of anterior pituitary tumors behave benignly, that is, they grow slowly and do not
metastasize, and were therefore called adenomas. However, they would frequently invade …

We report two pituitary neuroendocrine tumors (PitNETs) with very high Ki67 labeling
indices, many mitoses and TP53 mutation (nearly all tumor cell nuclei were positive for p53) …

High-risk pituitary adenomas are aggressive. They show clinical and imaging features
similar to those of carcinomas, including infiltration of the surrounding brain structures, but …