Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells
and shrink tumors. Although great success has been achieved on radiotherapy, there is still …

Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a
large challenge to enhance radiation damage to tumor tissue and reduce side effects to …

Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The …

Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Inactivation of cancer stem cells (CSCs) is of utmost importance for tumor cure after
radiotherapy. An increasing body of evidence complies with a higher radioresistance of …

Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …