Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Aggregation of amyloid-β (Aβ) by self-assembly into oligomers or amyloids is a central event
in Alzheimer's disease. Coordination of transition-metal ions, mainly copper and zinc, to Aβ …

Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

In the present perspective, we give a critical review on the coordination chemistry of the
metal ions copper and zinc to the amyloid-β (Aβ) peptide; such complexes have been linked …

Although a key factor in Alzheimer's disease etiology is enrichment of Zn2+ in aggregates,
and there are data suggesting that zinc promotes aggregation, how Zn2+-A β coordination …

The equilibrium of metal ions is critical for many physiological functions, particularly in the
central nervous system, where metals are essential for development and maintenance of …

The metal ions copper, zinc and iron have been shown to be involved in Alzheimer's
disease (AD). Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD …

Amyloids can have normal biological functions. 1r3 However, amyloidogenic proteins can
also form unwanted oligomeric or polymeric aggregates when disturbed from their native …

There is increasing evidence to support a role for both the amyloid β-protein precursor
(AβPP) and its proteolytic fragment, amyloid β (Aβ), in metal ion homeostasis. Furthermore …