[HTML][HTML] Comparative analysis of aducanumab, zagotenemab and pioglitazone as targeted treatment strategies for Alzheimer's disease

M Abyadeh, V Gupta, V Gupta, N Chitranshi… - Aging and …, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the leading cause of dementia that has remained a major
medical, sociocultural and economical challenge globally. Previously developed treatments …

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

MMI Abdalla - World Journal of Diabetes, 2024 - pmc.ncbi.nlm.nih.gov
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that
have seen a rising prevalence worldwide. Recent studies have indicated a possible link …

Inflammation and insulin resistance as risk factors and potential therapeutic targets for Alzheimer's disease

A Vinuesa, C Pomilio, A Gregosa… - Frontiers in …, 2021 - frontiersin.org
Overnutrition and modern diets containing high proportions of saturated fat are among the
major factors contributing to a low-grade state of inflammation, hyperglycemia and …

PPAR agonists for the treatment of neuroinflammatory diseases

C Titus, MT Hoque, R Bendayan - Trends in Pharmacological Sciences, 2024 - cell.com
Peroxisome proliferator-activated receptors [PPARs; PPARα, PPARβ/δ (also known as
PPARδ), and PPARγ] widely recognized for their important role in glucose/lipid homeostasis …

Polarization of microglia and its therapeutic potential in sepsis

LVG Castro, CF Gonçalves-de-Albuquerque… - International Journal of …, 2022 - mdpi.com
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection, leaving the inflammation process without a proper resolution, leading to tissue …

Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK …

MA Salem, B Budzyńska, J Kowalczyk… - Toxicology and applied …, 2021 - Elsevier
Sporadic Alzheimer's disease (SAD) is a slowly progressive neurodegenerative disorder.
This study aimed to investigate neuroprotective potential of tadalafil (TAD) and bergapten …

Repurposing of anti-diabetic agents as a new opportunity to alleviate cognitive impairment in neurodegenerative and neuropsychiatric disorders

Q Chen, T Cao, NN Li, C Zeng, S Zhang… - Frontiers in …, 2021 - frontiersin.org
Cognitive impairment is a shared abnormality between type 2 diabetes mellitus (T2DM) and
many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) …

Aqueous extract of Ceratonia siliqua L. leaves elicits antioxidant, anti‐inflammatory, and AChE inhibiting effects in amyloid‐β42‐induced cognitive deficit mice: Role …

NS El Sayed, S Abidar, M Nhiri, L Hritcu… - Phytotherapy …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder attributed to several
etiological factors including cholinergic dysregulation, neuroinflammation, oxidative stress, β …

Selective PPAR-Delta/PPAR-gamma activation improves cognition in a model of Alzheimer's disease

I Steinke, M Govindarajulu, PD Pinky, J Bloemer, S Yoo… - Cells, 2023 - mdpi.com
Background: The continuously increasing association of Alzheimer's disease (AD) with
increased mortality rates indicates an unmet medical need and the critical need for …

Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review

DZ Oumeddour, S Al-Dalali, L Zhao, L Zhao… - Biochemical and …, 2024 - Elsevier
Anthocyanins, found in various pigmented plants as secondary metabolites, represent a
class of dietary polyphenols known for their bioactive properties, demonstrating health …