The use of Cannabis for medicinal purposes has been documented since ancient times,
where one of its principal cannabinoids extracted from Cannabis sativa, cannabidiol (CBD) …

Introduction Tramadol is widely being used in chronic pain management for improving
patients' life quality and reducing trauma. Although it is listed in several medicinal …

Tramadol is an opioid used as analgesic for treating moderate or sever pain. The long-term
use of tramadol can induce several deleterious effects. We investigated the impact of chronic …

Tramadol (TRA) causes neurotoxicity whereas trimetazidine (TMZ) is neuroprotective. The
potential involvement of the PI3K/Akt/mTOR signaling pathway in the neuroprotection of TMZ …

Purpose Dopamine transporter (DAT) imaging is used to support the diagnosis of
neurodegenerative parkinsonian disorders. Specific medications have been reported to …

Seizures are a common neurological disorder that affects people of all ages. These sudden,
uncontrolled electrical disturbances in the brain can cause a variety of symptoms, including …

Tramadol (TR) is a centrally acting analgesic drug that is used to relieve pain. The
therapeutic (0.1–0.8 mg/l), toxic (1–2 mg/l) and lethal (> 2 mg/l) ranges were reported for TR …

Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/
norepinephrine reuptake-inhibitor) that structurally resembles codeine and morphine. Given …

Background Tramadol is a widely used synthetic opioid for moderate to severe pain. Some
studies have shown that tramadol can increase oxidative stress in different tissues of the …

The current study was performed to study the tramadol HCL toxic effects on the brain, liver,
and kidney of adult male rats. Forty male adult albino rats were divided into 4 groups; the …