[HTML][HTML] Novelty and dopaminergic modulation of memory persistence: a tale of two systems
Adaptation to the ever-changing world is critical for survival, and our brains are particularly
tuned to remember events that differ from previous experiences. Novel experiences induce …
tuned to remember events that differ from previous experiences. Novel experiences induce …
Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
Update on the mechanism of action of aripiprazole: translational insights into antipsychotic strategies beyond dopamine receptor antagonism
Dopamine partial agonism and functional selectivity have been innovative strategies in the
pharmacological treatment of schizophrenia and mood disorders and have shifted the …
pharmacological treatment of schizophrenia and mood disorders and have shifted the …
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
L Wen, YS Lu, XH Zhu, XM Li… - Proceedings of the …, 2010 - National Acad Sciences
Neuregulin 1 (NRG1) is a trophic factor thought to play a role in neural development. Recent
studies suggest that it may regulate neurotransmission, mechanisms of which remain …
studies suggest that it may regulate neurotransmission, mechanisms of which remain …
Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders
Prefrontal cortex (PFC) mediates an assortment of cognitive functions including working
memory, behavioral flexibility, attention, and future planning. Unlike the hippocampus …
memory, behavioral flexibility, attention, and future planning. Unlike the hippocampus …
Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive
ZB Rosen, S Cheung, SA Siegelbaum - Nature neuroscience, 2015 - nature.com
Dopamine (DA) is required for hippocampal-dependent memory and long-term potentiation
(LTP) at CA1 Schaffer collateral (SC) synapses. It is therefore surprising that exogenously …
(LTP) at CA1 Schaffer collateral (SC) synapses. It is therefore surprising that exogenously …
Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus
D Vullhorst, J Neddens, I Karavanova… - Journal of …, 2009 - Soc Neuroscience
NRG1 and ERBB4 have emerged as some of the most reproducible schizophrenia risk
genes. Moreover, the Neuregulin (NRG)/ErbB4 signaling pathway has been implicated in …
genes. Moreover, the Neuregulin (NRG)/ErbB4 signaling pathway has been implicated in …
The importance of the NRG-1/ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric disorders
A Shamir, OB Kwon, I Karavanova… - Journal of …, 2012 - Soc Neuroscience
Neuregulin 1 (NRG-1) and its receptor ErbB4 have emerged as biologically plausible
schizophrenia risk factors, modulators of GABAergic and dopaminergic neurotransmission …
schizophrenia risk factors, modulators of GABAergic and dopaminergic neurotransmission …
The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits
A Buonanno - Brain research bulletin, 2010 - Elsevier
Numerous genetic linkage and association studies implicate members of the Neuregulin-
ErbB receptor (NRG-ErbB) signaling pathway as schizophrenia “at risk” genes. An emphasis …
ErbB receptor (NRG-ErbB) signaling pathway as schizophrenia “at risk” genes. An emphasis …
Specific regulation of NRG1 isoform expression by neuronal activity
Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development,
neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated …
neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated …