NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
N Đukić, Ø Strømland, JD Elsborg, D Munnur, K Zhu… - Science …, 2023 - science.org
PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …
transcription, and DNA replication stress management. However, little is known about the …
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
Inhibitors of PARP: Number crunching and structure gazing
Selective inhibitors of PARP1 and PARP2 (PARP1/2) are used to treat cancer patients with
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
EJ Longarini, H Dauben, C Locatelli, AR Wondisford… - Molecular Cell, 2023 - cell.com
PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …
DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
K Zhu, MJ Suskiewicz, A Hloušek-Kasun, H Meudal… - Science …, 2022 - science.org
Ubiquitylation had been considered limited to protein lysine residues, but other substrates
have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3 …
have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3 …
Updated protein domain annotation of the PARP protein family sheds new light on biological function
MJ Suskiewicz, D Munnur, Ø Strømland… - Nucleic Acids …, 2023 - academic.oup.com
AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …
through their ability to accurately predict protein structures. In the present work, we explored …
Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
S Bilokapic, MJ Suskiewicz, I Ahel, M Halic - Nature, 2020 - nature.com
Breaks in DNA strands recruit the protein PARP1 and its paralogue PARP2 to modify
histones and other substrates through the addition of mono-and poly (ADP-ribose)(PAR) …
histones and other substrates through the addition of mono-and poly (ADP-ribose)(PAR) …