Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Precise timing in hormone release from the hypothalamus, the pituitary and ovary is critical
for fertility. Hormonal release patterns of the reproductive axis are regulated by a feedback …

Over the past two decades, it has become clear just how much of our physiology is under the
control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks …

The circadian rhythm, which is necessary for reproduction, is controlled by clock genes. In
the mouse uterus, the oscillation of the circadian clock gene has been observed. The …

Reproduction, like many other biological functions, exhibits marked daily and seasonal
rhythms in order to anticipate and adapt breeding activity to environmental challenges. In …

Context: Kisspeptin is the most powerful known stimulus of GnRH-induced LH secretion
across mammalian species. However, the effects of kisspeptin are just being explored, and …

Female reproduction requires the precise temporal organization of interacting, estradiol-
sensitive neural circuits that converge to optimally drive hypothalamo-pituitary–gonadal …

Throughout most of the ovulatory cycle, estrogen negative feedback restrains the GnRH
neuronal system. Just before ovulation, however, estrogen negative feedback is removed to …

Burst firing of neurons optimizes neurotransmitter release. GnRH neurons exhibit burst firing
activity and T-type calcium channels, which are vital for burst firing activity, are regulated by …

Recent strides in circadian biology over the last several decades have allowed researchers
new insight into how molecular circadian clocks influence the broader physiology of …