It has been a decade since it was discovered that primary cilia have an essential role in
Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that …

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Wild animals and plants have developed a variety of adaptive traits driven by adaptive
evolution, an important strategy for species survival and persistence. Uncovering the …

Phenotypic convergence between distantly related taxa often mirrors adaptation to similar
selective pressures and may be driven by genetic convergence. The giant panda …

Ubiquitous in nature, cilia and flagella comprise nearly identical structures with similar
functions. The most obvious example of the latter is motility: driving movement of the …

In the last 10 years, the primary cilia machinery has been implicated in more than a dozen
disorders united as ciliopathies, including skeletal dysplasias, such as Jeune syndrome and …

Dynein-2 assembles with polymeric intraflagellar transport (IFT) trains to form a transport
machinery that is crucial for cilia biogenesis and signaling. Here we recombinantly …

Background Whereas cilia damage and reduced cilia beat frequency have been implicated
as causative of reduced mucociliary clearance in smokers, theoretically mucociliary …

Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular signaling.
Ciliopathies are a spectrum of human diseases resulting from defects in cilia structure or …

Defects in the biosynthesis and/or function of primary cilia cause a spectrum of disorders
collectively referred to as ciliopathies. A subset of these disorders is distinguished by …