Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Type 2 diabetes mellitus (T2DM) is the most common human endocrine disease and is
characterized by peripheral insulin resistance and pancreatic islet β‐cell failure …

The human genome expresses nine patatin-like phospholipase domain containing proteins
(PNPLA1–9). Members of this family share a protein domain discovered initially in patatin …

Abstract Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of
glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 …

Abstract Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical
activity. Changes of the membrane potential (V m) are regulated by metabolism-dependent …

Nanospray Desorption Electrospray Ionization mass spectrometry imaging (nano-DESI MSI)
enables ambient imaging of biological samples with high sensitivity and minimal sample …

Among the emerging phospholipase A2 (PLA2) superfamily, the secreted PLA2 (sPLA2)
family consists of low-molecular-mass, Ca2+-requiring extracellular enzymes with a His-Asp …

The function and survival of pancreatic β cells critically rely on complex electrical signaling
systems composed of a series of ionic events, namely fluxes of K+, Na+, Ca 2+ and Cl …

Fatty acids (FAs), as part of lipids, are involved in cell membrane composition, cellular
energy storage, and cell signaling. FAs can also be toxic when their concentrations inside …