Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
m3C32 tRNA modification controls serine codon-biased mRNA translation, cell cycle, and DNA-damage response
The epitranscriptome includes a diversity of RNA modifications that influence gene
expression. N3-methylcytidine (m3C) mainly occurs in the anticodon loop (position C32) of …
expression. N3-methylcytidine (m3C) mainly occurs in the anticodon loop (position C32) of …
Engineered mischarged transfer RNAs for correcting pathogenic missense mutations
Missense mutations account for approximately 50% of pathogenic mutations in human
genetic diseases, and most lack effective treatments. Gene therapies, gene editing, and …
genetic diseases, and most lack effective treatments. Gene therapies, gene editing, and …
METTLing in stem cell and cancer biology
JG Tooley, JP Catlin, CES Tooley - Stem cell reviews and reports, 2023 - Springer
The methyltransferase-like (METTL) family is a diverse group of methyltransferases that can
methylate nucleotides, proteins, and small molecules. Despite this diverse array of …
methylate nucleotides, proteins, and small molecules. Despite this diverse array of …
The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation
N Kleiber, N Lemus-Diaz, C Stiller, M Heinrichs… - Nature …, 2022 - nature.com
Modified nucleotides in tRNAs are important determinants of folding, structure and function.
Here we identify METTL8 as a mitochondrial matrix protein and active RNA …
Here we identify METTL8 as a mitochondrial matrix protein and active RNA …
Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8
MH Huang, GX Peng, XL Mao, JT Wang… - Nucleic acids …, 2022 - academic.oup.com
METTL8 has recently been identified as the methyltransferase catalyzing 3-methylcytidine
biogenesis at position 32 (m3C32) of mitochondrial tRNAs. METTL8 also potentially …
biogenesis at position 32 (m3C32) of mitochondrial tRNAs. METTL8 also potentially …
Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease
T Yu, Y Zhang, WQ Zheng, S Wu, G Li… - Nucleic Acids …, 2022 - academic.oup.com
Mitochondrial translation is of high significance for cellular energy homeostasis. Aminoacyl-
tRNA synthetases (aaRSs) are crucial translational components. Mitochondrial aaRS …
tRNA synthetases (aaRSs) are crucial translational components. Mitochondrial aaRS …
Roles and dynamics of 3-methylcytidine in cellular RNAs
KE Bohnsack, N Kleiber, N Lemus-Diaz… - Trends in biochemical …, 2022 - cell.com
Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability,
and function. As reviewed here, 3-methylcytidine (m 3 C) has recently come to the fore …
and function. As reviewed here, 3-methylcytidine (m 3 C) has recently come to the fore …
Multifaceted roles of t6A biogenesis in efficiency and fidelity of mitochondrial gene expression
Y Zhang, JB Zhou, Y Yin, ED Wang… - Nucleic Acids …, 2024 - academic.oup.com
Abstract N 6-Threonylcarbamoyladenosine at A37 (t6A37) of ANN-decoding transfer RNAs
(tRNAs) is a universal modification whose functions have been well documented in bacteria …
(tRNAs) is a universal modification whose functions have been well documented in bacteria …