Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Organs-on-chips at the frontiers of drug discovery
Improving the effectiveness of preclinical predictions of human drug responses is critical to
reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication …
reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication …
Personalized cancer medicine: an organoid approach
Personalized cancer therapy applies specific treatments to each patient. Using personalized
tumor models with similar characteristics to the original tumors may result in more accurate …
tumor models with similar characteristics to the original tumors may result in more accurate …
Recent advances in microfluidic technologies for cell-to-cell interaction studies
Microfluidic cell cultures are ideally positioned to become the next generation of in vitro
diagnostic tools for biomedical research, where key biological processes such as cell …
diagnostic tools for biomedical research, where key biological processes such as cell …
Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational research
N Ahmed, KL Stenvers - Frontiers in oncology, 2013 - frontiersin.org
More than one third of ovarian cancer patients present with ascites at diagnosis, and almost
all have ascites at recurrence. The presence of ascites correlates with the peritoneal spread …
all have ascites at recurrence. The presence of ascites correlates with the peritoneal spread …
Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis
The possibility of detecting and classifying living cells in a label-free and non-invasive
manner holds significant theranostic potential. In this work, Hyperspectral Imaging (HSI) has …
manner holds significant theranostic potential. In this work, Hyperspectral Imaging (HSI) has …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …