Oxygen-derived free radicals and related oxidants are ubiquitous and short-lived
intermediates formed in aerobic organisms throughout life. These reactive species …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …

Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from
reactive oxygen species (ROS). Decreased levels of SODs or mutations that affect their …

Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

Peroxynitrite is formed by the very fast reaction of nitric oxide and superoxide radicals, a
reaction that kinetically competes with other routes that chemically consume or physically …

This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

Increased understanding of the role of mitochondria under physiological and pathological
conditions parallels increased exploration of synthetic and natural compounds able to mimic …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Peroxynitrite promotes oxidative damage and is implicated in the pathophysiology of various
diseases that involve accelerated rates of nitric oxide and superoxide formation. The …