Cell migration is dependent on the dynamic formation and disassembly of actin filament–
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …

In most tissues, the precise control of cell migration and cell-cell interaction is of paramount
importance to the development of a functional structure. Several families of secreted …

Pilocytic astrocytomas (PAs), WHO malignancy grade I, are the most frequently occurring
central nervous system tumour in 5-to 19-year-olds. Recent reports have highlighted the …

We report genetic aberrations that activate the ERK/MAP kinase pathway in 100% of
posterior fossa pilocytic astrocytomas, with a high frequency of gene fusions between …

Abstract Background Genome-wide Association Studies (GWAS) have proved invaluable for
the identification of disease susceptibility genes. However, the prioritization of candidate …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

Idiopathic pulmonary fibrosis (IPF) is a complex disease in which a multitude of proteins and
networks are disrupted. Interrogation of the transcriptome through RNA sequencing (RNA …

Malignant gliomas are the most common and the deadliest brain malignancies in adults.
Despite the lack of a complete understanding of the biology of these tumors, significant …

Low‐grade astrocytomas (LGAs) are the most common type of brain tumor in children. Until
recently, very little was known about the underlying biology and molecular genetics of these …

Mental retardation (MR) is a common cause of intellectual disability and affects
approximately 2 to 3% of children and young adults. Many forms of MR are associated with …