Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia

S Kiehlmeier, MR Rafiee, A Bakr, J Mika, S Kruse… - Leukemia, 2021 - nature.com
Deregulation of the EVI1 proto-oncogene by the GATA2 distal hematopoietic enhancer
(G2DHE) is a key event in high-risk acute myeloid leukemia carrying 3q21q26 aberrations …

A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high‐risk …

C Saygin, K Larkin, JS Blachly, S Orwick… - American Journal of …, 2020 - Wiley Online Library
Patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) have poor outcomes
and hematopoietic cell transplantation (HCT) is the only curative treatment. New targeted …

A Pediatric Case of Treatment-related Myelodysplastic Syndrome While on Therapy for Pre-B Acute Lymphoblastic Leukemia

S McElroy, GD Myers, T Flatt - Journal of Pediatric Hematology …, 2023 - journals.lww.com
Background: Treatment-related myelodysplastic syndrome (t-MDS) is a rare late effect of
cancer therapy. After alkylating agents, this typically occurs years after completion of …