Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

Inhibition of protein–protein interactions (PPIs) represents a significant challenge because it
is unclear how they can be effectively and selectively targeted using small molecules …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Because of its importance to the arthropod exoskeleton, chitin biogenesis is an attractive
target for pest control. This point is demonstrated by the economically important benzoylurea …

Chitin is the most abundant natural aminopolysaccharide and serves as a structural
component of extracellular matrices. It is found in fungal septa, spores, and cell walls, and in …

Targeting protein–protein interactions (PPIs) has emerged as a viable approach in modern
drug discovery. However, the identification of small molecules enabling us to effectively …

Many biological processes are regulated by protein–protein interactions (PPIs) and as such
their misregulation can cause a multitude of diseases. Often the interactions between large …

The unique hydrogen binding capabilities of ureas make them an important functional group
to make drug-target interactions and thus incorporated in small molecules displaying broad …

Abstract Protein‐Protein‐Interaktionen (PPIs) spielen auf allen Ebenen der Zellorganisation
eine wichtige Rolle, was die Entwicklung von PPI‐Inhibitoren äußerst interessant macht. Die …