Trends and challenges in neuroengineering: toward “intelligent” neuroprostheses through brain-“brain inspired systems” communication

S Vassanelli, M Mahmud - Frontiers in neuroscience, 2016 - frontiersin.org
Future technologies aiming at restoring and enhancing organs function will intimately rely on
near-physiological and energy-efficient communication between living and artificial …

Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders

A de Rus Jacquet, HL Denis, F Cicchetti… - Molecular …, 2021 - nature.com
Neurodegenerative disorders emerge from the failure of intricate cellular mechanisms,
which ultimately lead to the loss of vulnerable neuronal populations. Research conducted …

An integrated microfluidic/microelectrode array for the study of activity-dependent intracellular dynamics in neuronal networks

E Moutaux, B Charlot, A Genoux, F Saudou… - Lab on a Chip, 2018 - pubs.rsc.org
In the central nervous system, neurons are organized in specific neural networks with
distinct electrical patterns, input integration capacities, and intracellular dynamics. In order to …

A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers

S Gribi, S du Bois de Dunilac, D Ghezzi… - Nature …, 2018 - nature.com
Peripheral nerves are anisotropic and heterogeneous neural tissues. Their complex
physiology restricts realistic in vitro models, and high resolution and selective probing of …

Influence of microchannel geometry on device performance and electrophysiological recording fidelity during long-term studies of connected neural populations

N Goshi, G Girardi, F da Costa Souza, A Gardner… - Lab on a Chip, 2022 - pubs.rsc.org
Compartmentalized microfluidic neural cell culture platforms, which physically separate
axons from the neural soma using a series of microchannels, have been used for studying a …

A multielectrode array microchannel platform reveals both transient and slow changes in axonal conduction velocity

R Habibey, S Latifi, H Mousavi, M Pesce… - Scientific Reports, 2017 - nature.com
Due to their small dimensions, electrophysiology on thin and intricate axonal branches in
support of understanding their role in normal and diseased brain function poses …

Bidirectional flow of action potentials in axons drives activity dynamics in neuronal cultures

JC Mateus, CDF Lopes, M Aroso… - Journal of neural …, 2021 - iopscience.iop.org
Objective. Recent technological advances are revealing the complex physiology of the axon
and challenging long-standing assumptions. Namely, while most action potential (AP) …

Branching morphology determines signal propagation dynamics in neurons

N Ofer, O Shefi, G Yaari - Scientific reports, 2017 - nature.com
Computational modeling of signal propagation in neurons is critical to our understanding of
basic principles underlying brain organization and activity. Exploring these models is used …

Functional imaging of conduction dynamics in cortical and spinal axons

M Radivojevic, AR Punga - Elife, 2023 - elifesciences.org
Mammalian axons are specialized for transmitting action potentials to targets within the
central and peripheral nervous system. A growing body of evidence suggests that, besides …

Characterization of axonal spikes in cultured neuronal networks using microelectrode arrays and microchannel devices

N Hong, S Joo, Y Nam - IEEE Transactions on Biomedical …, 2016 - ieeexplore.ieee.org
Objective: Axonal propagation has a pivotal role in information processing in the brain.
However, there has been little experimental study due to the difficulty of isolation of axons …