Simple Summary Induced pluripotent stem cells (iPSCs) that can be genetically engineered
and differentiated into different types of immune cells, providing an unlimited resource for …

The development of methods to derive induced pluripotent stem cells (iPSCs) has propelled
stem cell research, and has the potential to revolutionize many areas of medicine, including …

Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited resource for
cell therapies, but the derivation of mature cell types remains challenging. The histone …

Cellular differentiation requires extensive alterations in chromatin structure and function,
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …

The Notch signaling pathway has fundamental roles in embryonic development and in the
nervous system. The current model of receptor activation involves initiation via a force …

T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T
cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the …

The thymus, a primary lymphoid organ, produces the T cells of the immune system.
Originating from the 3rd pharyngeal pouch during embryogenesis, this organ functions …

Chimeric antigen receptor T cell (CAR-T) therapy is novel tumor immunotherapy that
enables autologous T to express synthetic receptors to specifically recognize the surface …

The haematopoietic system plays an essential role in our health and survival. It is comprised
of a range of mature blood and immune cell types, including oxygen-carrying erythrocytes …

The Notch pathway regulates cell fate decisions and is an emerging target for regenerative
and cancer therapies. Recombinant Notch ligands are attractive candidates for modulating …