The chemistry and biological activities of peptides from amphibian skin secretions

X Xu, R Lai - Chemical reviews, 2015 - ACS Publications
Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

Advancement in leishmaniasis diagnosis and therapeutics: An update

D Kumari, S Perveen, R Sharma, K Singh - European Journal of …, 2021 - Elsevier
Leishmaniasis is regarded as a neglected tropical disease by World Health Organization
(WHO) and is ranked next to malaria as the deadliest protozoan disease. The primary …

Biological function of antimicrobial peptides on suppressing pathogens and improving host immunity

Z Lyu, P Yang, J Lei, J Zhao - Antibiotics, 2023 - mdpi.com
The emergence of drug-resistant genes and concerns about food safety caused by the
overuse of antibiotics are becoming increasingly prominent. There is an urgent need for …

Antimicrobial peptide action on parasites

M Torrent, D Pulido, L Rivas, D Andreu - Current drug targets, 2012 - ingentaconnect.com
Diseases caused by protozoan parasites can pose a severe thread to human health and are
behind some serious neglected tropical diseases like malaria and leishmaniasis. Though …

Trypanosoma cruzi Immune Response Modulation Decreases Microbiota in Rhodnius prolixus Gut and Is Crucial for Parasite Survival and Development

DP Castro, CS Moraes, MS Gonzalez, NA Ratcliffe… - PLoS …, 2012 - journals.plos.org
Trypanosoma cruzi in order to complete its development in the digestive tract of Rhodnius
prolixus needs to overcome the immune reactions and microbiota trypanolytic activity of the …

Emerging therapeutic targets for treatment of leishmaniasis

S Sundar, B Singh - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

D Smirlis, M Duszenko, AJ Ruiz, E Scoulica… - Parasites & vectors, 2010 - Springer
Apoptosis is a normal component of the development and health of multicellular organisms.
However, apoptosis is now considered a prerogative of unicellular organisms, including the …

[HTML][HTML] Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways

CM Adade, IRS Oliveira, JAR Pais, T Souto-Padrón - Toxicon, 2013 - Elsevier
Antimicrobial peptides (AMPs) are components of the innate immune response that
represent desirable alternatives to conventional pharmaceuticals, as they have a fast mode …

Preparation, in-vitro and in-vivo evaluation of Rifampicin and Vancomycin Co-loaded transfersomal gel for the treatment of cutaneous leishmaniasis

MW Salim, K Shabbir, AM Yousaf, HG Choi… - Journal of Drug Delivery …, 2020 - Elsevier
Targeted and localized drug delivery via dermal route is an effective approach to improve
drug delivery and reduce drugs associated toxicities, most particularly treating cutaneous …

Antichagasic effect of crotalicidin, a cathelicidin-like vipericidin, found in Crotalus durissus terrificus rattlesnake's venom gland

ICJ Bandeira, D Bandeira-Lima, CP Mello, TP Pereira… - Parasitology, 2018 - cambridge.org
Cathelicidins are antimicrobial peptides produced by humans and animals in response to
various pathogenic microbes. Crotalicidin (Ctn), a cathelicidin-related vipericidin from the …