In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an
alkyne and an amine, commonly called A3-coupling, has been established as a convenient …

Asymmetric A3 coupling has emerged as an important class of reactions to synthesise chiral
propargylamines. In this tutorial review, an up to date progress of this reaction, with …

Over the past decade, large strides have been achieved in the invention of methods for the
direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral …

The catalytic asymmetric addition reactions of organometallic reagents to CdN double bonds
of imines are fundamentally important processes, which provide convenient and versatile …

Zinc is the 24th most abundant element in the Earth's crust. Since the discovery of pure zinc
metal in the 18th century, the main application of zinc metal is as materials. Because zinc …

Impregnated copper on magnetite is a versatile, inexpensive and simple catalyst for the
selective multicomponent reaction of terminal alkynes, aldehydes and secondary amines to …

Since the first definition of domino reactions by Tietze in 1993, an explosive number of these
fascinating reactions has been developed, allowing the easily building of complex chiral …

Mechanistic studies and expansion of the substrate scope of direct enantioselective
alkynylation of α-ketiminoesters catalyzed by adaptable (phebox) rhodium (III) complexes …

Propargylamines are synthesized in high yields via a gold (III)(C^ N) complex-catalyzed
three-component coupling reaction of aldehydes, amines and alkynes in water at 40° C …