A subset of cancers across multiple histologies with predominantly poor outcomes use the
alternative lengthening of telomeres (ALT) mechanism to maintain telomere length, which …

Mutations in tumor suppressor genes, such as Tumor Protein 53 (TP53), are heavily
implicated in aggressive cancers giving rise to gain-and loss-of-function phenotypes. While …

The heterogeneity and complexity of solvent-extracted organic matter associated with PM
2.5 (SEOM-PM 2.5) is well known; however, there is scarce information on its biological …

The tumor suppressor protein TP53 (p53) plays a multifaceted role in all cells of the human
body. Mutations in the TP53 gene are often involved in cancer induction and disease …

Decades of research have focused on the role of the TP53 gene in healthy cells and disease
progression. The p53 protein, commonly called the “guardian of the genome,” orchestrates …