The gut microbiota and its biogeography

G McCallum, C Tropini - Nature Reviews Microbiology, 2024 - nature.com
Biogeography is the study of species distribution and diversity within an ecosystem and is at
the core of how we understand ecosystem dynamics and interactions at the macroscale. In …

Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

W Yang, T Yu, X Huang, AJ Bilotta, L Xu, Y Lu… - Nature …, 2020 - nature.com
Innate lymphoid cells (ILCs) and CD4+ T cells produce IL-22, which is critical for intestinal
immunity. The microbiota is central to IL-22 production in the intestines; however, the factors …

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

P Paone, PD Cani - Gut, 2020 - gut.bmj.com
The gastrointestinal tract is often considered as a key organ involved in the digestion of food
and providing nutrients to the body for proper maintenance. However, this system is …

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

SA Kerk, T Papagiannakopoulos, YM Shah… - Nature Reviews …, 2021 - nature.com
Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

S Jalili-Firoozinezhad, FS Gazzaniga… - Nature biomedical …, 2019 - nature.com
The diverse bacterial populations that comprise the commensal microbiome of the human
intestine play a central role in health and disease. A method that sustains complex microbial …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease

K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

Gut microbiota and IBD: causation or correlation?

J Ni, GD Wu, L Albenberg, VT Tomov - Nature reviews Gastroenterology …, 2017 - nature.com
A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …

Trophic interactions and the drivers of microbial community assembly

M Gralka, R Szabo, R Stocker, OX Cordero - Current Biology, 2020 - cell.com
Despite numerous surveys of gene and species content in heterotrophic microbial
communities, such as those found in animal guts, oceans, or soils, it is still unclear whether …