ROS homeostasis and metabolism: a dangerous liason in cancer cells

E Panieri, MM Santoro - Cell death & disease, 2016 - nature.com
Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …

The metabolic mechanisms of breast cancer metastasis

L Wang, S Zhang, X Wang - Frontiers in Oncology, 2021 - frontiersin.org
Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

Dietary fructose improves intestinal cell survival and nutrient absorption

SR Taylor, S Ramsamooj, RJ Liang, A Katti… - Nature, 2021 - nature.com
Fructose consumption is linked to the rising incidence of obesity and cancer, which are two
of the leading causes of morbidity and mortality globally,. Dietary fructose metabolism …

Glucose transporters as a target for anticancer therapy

M Pliszka, L Szablewski - Cancers, 2021 - mdpi.com
Simple Summary For mammalian cells, glucose is a major source of energy. In the presence
of oxygen, a complete breakdown of glucose generates 36 molecules of ATP from one …

High-fructose corn syrup enhances intestinal tumor growth in mice

MD Goncalves, C Lu, J Tutnauer, TE Hartman… - Science, 2019 - science.org
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is
associated with obesity and with an increased risk of colorectal cancer. Whether HFCS …

Glucose transporters: physiological and pathological roles

AM Navale, AN Paranjape - Biophysical reviews, 2016 - Springer
Glucose is a primary energy source for most cells and an important substrate for many
biochemical reactions. As glucose is a need of each and every cell of the body, so are the …

Glucose metabolism and glucose transporters in breast cancer

E Shin, JS Koo - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment

CC Barron, PJ Bilan, T Tsakiridis, E Tsiani - Metabolism, 2016 - Elsevier
It is long recognized that cancer cells display increased glucose uptake and metabolism. In
a rate-limiting step for glucose metabolism, the glucose transporter (GLUT) proteins facilitate …

Emerging roles of aerobic glycolysis in breast cancer

Z Wu, J Wu, Q Zhao, S Fu, J Jin - Clinical and Translational Oncology, 2020 - Springer
Altered aerobic glycolysis is a well-recognized characteristic of cancer cell energy
metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a …

Expression of glucose transporters in cancers

L Szablewski - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
It has been known for 80years that cancer cell growth in an energy-related process
supported by an increased glucose metabolism. This phenomenon suggests a need for a …