▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In
addition, there is increasing evidence that DCs in situ induce antigen-specific …

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of cells that play a
critical role in tumor associated immune suppression. In an attempt to identify a specific …

The immune system generally avoids horror autotoxicus or autoimmunity, an attack against
the body's own constituents. This avoidance requires that self-reactive T cells be actively …

Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible
individuals. Both naturally occurring CD4+ CD25+ regulatory T cells and inducible …

We studied the effects of 1α, 25-dihydroxyvitamin D 3 (1α, 25-(OH) 2 D 3) on differentiation,
maturation, and functions of dendritic cells (DC) differentiated from human monocytes in vitro …

Abstract Inflammatory T helper 1 (TH1)-cell responses successfully eradicate pathogens, but
often also cause immunopathology. To minimize this deleterious side-effect the anti …

Primary immune responses are initiated by dendritic cells (DCs), which inform naive T
helper (Th) cells about invading pathogens, providing an antigen-specific 'signal 1'and a …

The escape of malignant cells from the immune response against the tumor may result from
a defective differentiation or function of professional antigen-presenting cells (APC), ie …

IL-10 is a critical cytokine that blocks the maturation of dendritic cells (DCs), but the
relevance of autocrine IL-10 on DC functions has not been investigated. In this study, we …

Because dendritic cells (DC) play a major role in the initiation of T cell-mediated immunity,
we studied the effects of glucocorticoids, well-known inhibitors of the immune and …