Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …

Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body
to establish secondary tumors. Although this is an inefficient process, the consequences are …

Histone acetylation plays important roles in gene regulation, DNA replication, and the
response to DNA damage, and it is frequently deregulated in tumors. We postulated that …

Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such,
heterogeneity is one of the most important and clinically relevant areas of cancer research …

Breast cancer is not a single disease, but is instead a collection of diseases that have
distinct histopathological features, genetic and genomic variability, and diverse prognostic …

In triple-negative breast cancer (TNBC), stromal restriction of CD8+ T cells associates with
poor clinical outcomes and lack of responsiveness to immune-checkpoint blockade (ICB). To …

Breast cancer recurrence is a fundamental clinical manifestation of tumor progression and
represents the principal cause of death from this disease. Using a conditional transgenic …

Dormancy occurs when cells remain viable but stop proliferating. When most of a cancer
population undergoes this phenomenon, the result is called tumor dormancy, and when a …

Metastatic spread of cancer cells is the main cause of death of breast cancer patients, and
elucidation of the molecular mechanisms underlying this process is a major focus in cancer …

Activating Ras mutations can induce either proliferation or senescence depending on the
cellular context. To determine whether Ras activation has context-dependent effects in the …