The interferons (IFNs) are a family of cytokines that protect against disease by direct effects
on target cells and by activating immune responses. The production and actions of IFNs are …

Bone metastases cause significant morbidity and mortality in late-stage breast cancer
patients and are currently considered incurable. Investigators rely on translational models to …

Crk and CrkL are cellular counterparts of the viral oncoprotein v-Crk. Crk and CrkL are
overexpressed in many types of human cancer, correlating with poor prognosis …

Breast cancer (BC) represents the most incident cancer case in women (29%), with high
mortality rate. Bone metastasis occurs in 20–50% cases and, despite advances in BC …

Interferons (IFNs) are a group of signaling cytokines, secreted by host cells to induce
protection against various disorders. IFNs can directly impact on tumor cells or indirectly …

Locally advanced and metastatic invasive bladder cancer (BC) has a poor prognosis, and
no advanced therapies beyond cisplatin‐based combination chemotherapy have been …

The human chromosome 22q11. 2 region is susceptible to rearrangements during meiosis
leading to velo-cardio-facial/DiGeorge/22q11. 2 deletion syndrome (22q11DS) …

Although histone deacetylase (HDAC) inhibitors have been shown to effectively induce the
inhibition of proliferation and migration in breast cancer, the anticancer mechanism remains …

The tumor infiltration of immune cells in solid cancers can profoundly influence host
antitumor responses. In recent years, immunotherapeutic regimens, that target immune …

CrkII, a member of the adaptor protein family, is known to participate in bone homeostasis
via the regulation of osteoclasts and osteoblasts. Therefore, silencing CrkII would …