[HTML][HTML] Podophyllum hexandrum and its active constituents: Novel radioprotectants

U Anand, P Biswas, V Kumar, D Ray, P Ray… - Biomedicine & …, 2022 - Elsevier
Human exposure to radiation has expanded considerably in recent years, due to a wide
range of medical, agricultural, and industrial applications. Despite its beneficial utilities …

Appraisal of biochemical classes of radioprotectors: evidence, current status and guidelines for future development

K Mishra, G Alsbeih - 3 Biotech, 2017 - Springer
The search for efficient radioprotective agents to protect from radiation-induced toxicity, due
to planned or accidental radiation exposure, is still ongoing worldwide. Despite decades of …

[PDF][PDF] Conservation status, anticancer compounds and pharmacological aspects of royle: a review Podophyllum hexandrum

J Kumar, P Sandal, A Singh, A Kumar… - Indian Journal of …, 2022 - researchgate.net
Podophyllum hexandrum or Himalayan may apple is an endangered medicinal plant. The
plant is a major source of anticancer agent, podophyllotoxin. Podophyllotoxin content in is …

Plant extracts and plant-derived compounds: promising players in countermeasure strategy against radiological exposure: a review

L Kma - Asian Pacific Journal of Cancer Prevention, 2014 - koreascience.kr
Radiation exposure leads to several pathophysiological conditions, including oxidative
damage, inflammation and fibrosis, thereby affecting the survival of organisms. This review …

Modifying radiation damage

K Kim, W H. McBride - Current drug targets, 2010 - benthamdirect.com
Radiation leaves a fairly characteristic footprint in biological materials, but this is rapidly all
but obliterated by the canonical biological responses to the radiation damage. The innate …

Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain

RD Pearlstein, Y Higuchi, M Moldovan… - … journal of radiation …, 2010 - Taylor & Francis
Purpose: We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole)
porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo …

Podophyllum hexandrum‐Mediated Survival Protection and Restoration of Other Cellular Injuries in Lethally Irradiated Mice

S Sankhwar, ML Gupta, V Gupta… - Evidence‐Based …, 2011 - Wiley Online Library
This study aims at the development of a safe and effective formulation to counter the effects
of lethal irradiation. The sub‐fraction (G‐001M), prepared from Podophyllum hexandrum has …

[PDF][PDF] Some high value medicinal plants of Khumbu region Nepal

DS Rawal, J Sijapati, N Rana, P Rana… - Nepal Journal of …, 2009 - academia.edu
Visualizing the present biodiversity status of Nepal, an integrated approach comprising of
biodiversity documentation, bio-prospecting, sustainable utilization and conservation has …

[PDF][PDF] Whole body protection to lethally irradiated mice by oral administration of semipurified fraction of Podophyllum hexandrum and post irradiation treatment of …

ML Gupta, S Sankhwar, S Verma, M Devi… - Tokai J. Exp. Clin …, 2008 - academia.edu
Objective: to evaluate the radioprotective potential of alcoholic fraction of Podophyllum
hexandrum rhizomes (rEc-2001) individually as well as in combination with Picrorhiza …

[PDF][PDF] Radioprotective activities of Podophyllum hexandrum: current knowledge of the molecular mechanisms

R Kumar, PK Singh, R Arora, R Chawla… - Trees for life …, 2009 - academia.edu
Radiation is one of the most severe causes of oxidative stress mediated by free radical flux.
This flux interferes with oxidation/reduction-based physiological mechanisms existing inside …