The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …

Early stages of vascular development include endothelial cell differentiation in a network of
arteries, veins, and lymphatics. Subsequently, to respond to the specific needs of the organs …

Despite available therapies, myocardial infarction (MI) remains a leading cause of death
worldwide. Better understanding of the molecular and cellular mechanisms that regulate …

Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …

A wide variety of chronic diseases, such as neurodegenerative and cardiovascular
disorders, diabetes mellitus, osteoarthtitis, obesity and various cancers, are now being …

Oncogenic targets acting in both tumor cells and tumor stromal cells may offer special
therapeutic appeal. Interrogation of the Oncomine database revealed that 52 of 53 human …

Wingless/integrase-1 (WNT) signaling is a key pathway regulating various aspects of
embryonic development; however it also underlies several pathological conditions in man …

The Wnt/β-catenin signaling pathway plays a crucial role in the development, tissue
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …

The occludin-like proteins belong to a family of tetraspan transmembrane proteins carrying a
marvel domain. The intrinsic function of the occludin family is not yet clear. Occludin is a …

Wnt signaling is known to regulate multiple processes including angiogenesis, inflammation,
and fibrosis. Here, we identified a novel inhibitor of the Wnt pathway, pigment epithelium …