Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …

Abstract Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic
stress response and also represses inflammation. However, the mechanisms how Nrf2 …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

High-throughput chemical screens typically use coarse assays such as cell survival, limiting
what can be learned about mechanisms of action, off-target effects, and heterogeneous …

Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate
gene expression and are involved in cancer pathogenesis. Over the last years, several BET …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Improving effector activity of antigen-specific T cells is a major goal in cancer
immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …