Highlights•A comprehensive compilation and analysis of FDA approved and under clinical
trials peptide-based therapeutics.•Clinical trial peptides pipeline analysis reveals emerging …

The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

Amides are unquestionably one of the most important functional groups in organic chemistry
because of their presence in numerous interesting molecules such as peptides …

Amide bond forming reactions are critical for both polypeptide synthesis and medicinal
chemistry. Most current approaches for amidation employ stoichiometric activating agents …

In this Minireview, the importance and implementation of green chemistry practices in the
pharmaceutical industry are illustrated. With notable examples, some of the most important …

Chemical reactions for the formation of amide bonds are among the most commonly used
transformations in organic chemistry, yet they are often highly inefficient. A novel protocol for …

The expansion of molecular diversity beyond what nature can produce is a fundamental
objective in chemical sciences. Despite the rich chemistry of boron-containing heterocycles …

The generally accepted monoacyloxyboron mechanism of boron-catalysed direct amidation
is brought into question in this study, and new alternatives are proposed. We have carried …

Triarylsilanols have been reported as the first silicon-centered molecular catalysts for direct
amidation of carboxylic acids with amines as identified after a screen of silanols, silanediols …

Tetrakis (dimethylamido) diboron and tetrahydroxydiboron are herein reported as new
catalysts for the synthesis of aryl amides by catalytic condensation of aromatic carboxylic …