Although levothyroxine is one of the most prescribed medications in the world, its
bioavailability has been reported to be impaired by many factors, including interfering drugs …

Even though levothyroxine sodium pentahydrate tablets have been in the market since
1955, there continue to be recalls due to sub potency. We have comprehensively reviewed …

This work aimed to develop a subcutaneous implant for prolonged delivery of LEVO to treat
hypothyroidism. This could overcome challenges with patient compliance and co …

Levothyroxine is a drug with a narrow therapeutic index. Changing the drug formulation
composition or switching between pharmaceutical brands can alter the bioavailability, which …

Background Hypothyroidism is treated with daily levothyroxine (LT4). In recent years, soft gel
caps of LT4 (LT4-C) have been commercialized, and their performance has been optimized …

In recent years, continuous tablet manufacturing technology has been used to obtain
regulatory approval of several new drug products. While a significant fraction of active …

HPLC is an important research tool that can identify, extract and measure the substance, its
numerous components and drug-related additives that may occur during either the …