The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during
embryonic development and adult tissue homeostasis. Here we review the current …

Signalling by Wnt proteins is finely balanced to ensure normal development and tissue
homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a …

In order to achieve coordinated growth and patterning during development, cells must
communicate with one another, sending and receiving signals that regulate their activities …

Pattern formation during development is controlled to a great extent by a small number of
conserved signal transduction pathways that are activated by extracellular ligands such as …

Abstract Signalling by secreted Hedgehog (Hh) proteins is important for the development of
many tissues and organs. Damage to components of the Hh signal-transduction pathway …

During development, secreted morphogens such as Wnt, Hedgehog (Hh), and BMP emit
from their producing cells in a morphogenetic field, and specify different cell fates in a direct …

Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1).
However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1 …

Hedgehog (Hh) proteins are secreted signaling molecules that mediate essential tissue-
patterning events during embryonic development and function in tissue homeostasis and …

The positioning and elaboration of ectodermal veins in the wing of Drosophila melanogaster
rely on widely utilized developmental signals, including those mediated by EGF, BMP …