Prokaryotic genome regulation: multifactor promoters, multitarget regulators and hierarchic networks

A Ishihama - FEMS microbiology reviews, 2010 - academic.oup.com
The vast majority of experimental data have been accumulated on the transcription
regulation of individual genes within a single model prokaryote, Escherichia coli, which form …

Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi

SH Kirsch, FPJ Haeckl, R Müller - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Identification of Proteins Involved in the Heat Stress Response of Bacillus cereus ATCC 14579

PM Periago, W van Schaik, T Abee… - Applied and …, 2002 - Am Soc Microbiol
To monitor the ability of the food-borne opportunistic pathogen Bacillus cereus to survive
during minimal processing of food products, we determined its heat-adaptive response …

Prokaryotic genome regulation: a revolutionary paradigm

A Ishihama - Proceedings of the Japan Academy, Series B, 2012 - jstage.jst.go.jp
After determination of the whole genome sequence, the research frontier of bacterial
molecular genetics has shifted to reveal the genome regulation under stressful conditions in …

The evolving story of the omega subunit of bacterial RNA polymerase

R Mathew, D Chatterji - Trends in microbiology, 2006 - cell.com
Omega (ω) is the smallest subunit of bacterial RNA polymerase (RNAP). Although identified
early in RNAP research, its function remained ambiguous and shrouded by controversy for a …

Structure of the plant plastid-encoded RNA polymerase

Á Vergara-Cruces, I Pramanick, D Pearce, VK Vogirala… - Cell, 2024 - cell.com
Chloroplast genes encoding photosynthesis-associated proteins are predominantly
transcribed by the plastid-encoded RNA polymerase (PEP). PEP is a multi-subunit complex …

Response of RNA polymerase to ppGpp: requirement for the ω subunit and relief of this requirement by DksA

CE Vrentas, T Gaal, W Ross, RH Ebright… - Genes & …, 2005 - genesdev.cshlp.org
Previous studies have come to conflicting conclusions about the requirement for the ω
subunit of RNA polymerase in bacterial transcription regulation. We demonstrate here that …

Specific features of RNA polymerases I and III: structure and assembly

TW Turowski, M Boguta - Frontiers in molecular biosciences, 2021 - frontiersin.org
RNA polymerase I (RNAPI) and RNAPIII are multi-heterogenic protein complexes that
specialize in the transcription of highly abundant non-coding RNAs, such as ribosomal RNA …

Hierarchy of transcription factor network in Escherichia coli K-12: H-NS-mediated silencing and Anti-silencing by global regulators

A Ishihama, T Shimada - FEMS Microbiology Reviews, 2021 - academic.oup.com
Transcriptional regulation for genome expression determines growth and adaptation of
single-cell bacteria that are directly exposed to environment. The transcriptional apparatus …

Novel Mycobacterium tuberculosis anti‐σ factor antagonists control σF activity by distinct mechanisms

J Beaucher, S Rodrigue, PÉ Jacques… - Molecular …, 2002 - Wiley Online Library
The aetiological agent of tuberculosis, Mycobacterium tuberculosis, encodes 13 σ factors, as
well as several putative anti‐, and anti‐anti‐σ factors. Here we show that a σ factor that has …