Colorectal cancer (CRC) is a leading cause of preventable cancer deaths worldwide, with
dietary factors being recognised as key risk modifiers. Foods containing dietary fibre are …

Short-chain fatty acids (SCFA), particularly butyrate, were shown to regulate cell proliferation
in vitro and in vivo. Indeed, butyrate is the major fuel for colonic epithelial cells, and it can …

Butyrate is derived from the microbial metabolism of dietary fiber in the colon where it plays
an important role in linking colonocyte turnover and differentiation to luminal content. In …

Accumulating recent evidence indicates that the human microbiome plays essential roles in
pathophysiological states, including cancer. The tumor microbiome, an emerging concept …

Butyrate has a bioactive function to reduce carcinogenesis. To achieve targeted cancer
therapy, this study developed bacterial cancer therapy (BCT) with butyrate as a payload. By …

The use of oncolytic adenoviruses as a cancer therapeutic is dependent on the lytic
properties of the viral life cycle, and the molecular differences between tumor cells and …

The reversible acetylation of histones by histone deacetylases (HDACs) and
acetyltransferases (HATs) plays a fundamental role in gene transcription. We previously …

Sodium butyrate, a product of colonic fermentation of dietary fiber, has been shown to inhibit
cell proliferation by blocking the cells in the G1 phase of the cell cycle. However, its …

The structural and functional barrier preventing the free advancement of microbial plaque
subgingivally along the tooth surface is formed by the junctional epithelial (JE) cells directly …

Butyrate, a physiologically occurring agent, has been reported to decrease constitutively
high expressed p53 levels in transformed cells. To elucidate whether butyrate also inhibits …