[HTML][HTML] Checkpoint molecules on infiltrating immune cells in colorectal tumor microenvironment

IM Talaat, NM Elemam, S Zaher… - Frontiers in Medicine, 2022 - frontiersin.org
Colorectal cancer (CRC) is one of the most prevalent cancer types worldwide, with a high
mortality rate due to metastasis. The tumor microenvironment (TME) contains multiple …

[HTML][HTML] Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages

X Li, X Chen, S Gong, J Zhao, C Yao, H Zhu, R Xiao… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Platelets can influence the progression and prognosis of colorectal cancer (CRC)
through multiple mechanisms, including crosstalk with tumor-associated macrophages …

Structural comparison and expression function analysis of BF/C2 in Ctenopharyngodon idella and Squaliobarbus curriculus

Y Wei, Z Lv, Q Liu, J Yu, Y Xiao, Z Du, T Xiao - Fish & Shellfish Immunology, 2023 - Elsevier
Ctenopharyngodon idella and Squaliobarbus curriculus, members of the Cyprinidae family
and Yaroideae subfamily, have shown different levels of resistance to grass carp reo virus …

Interactions between MFAP5+ fibroblasts and tumor-infiltrating myeloid cells shape the malignant microenvironment of colorectal cancer

Z Peng, Z Ren, Z Tong, Y Zhu, Y Zhu, K Hu - Journal of Translational …, 2023 - Springer
Background The therapeutic targeting of the tumor microenvironment (TME) in colorectal
cancer (CRC) has not yet been fully developed and utilized because of the complexity of the …

Identification of DDX60 as a regulator of MHC-I class molecules in colorectal cancer

N Geng, T Hu, C He - Biomedicines, 2022 - mdpi.com
Immune checkpoint blockade (ICB) therapies induce durable responses in approximately
15% of colorectal cancer (CRC) patients who exhibit microsatellite instability-high (MSI-H) or …

[HTML][HTML] Ginsenoside modified lipid-coated perfluorocarbon nanodroplets: A novel approach to reduce complement protein adsorption and prolong in vivo circulation

J Zhou, B Gao, H Zhang, R Yang, J Huang, X Li… - … Pharmaceutica Sinica B, 2024 - Elsevier
Lipid-coated perfluorocarbon nanodroplets (lp-NDs) hold great promise in bio-medicine as
vehicles for drug delivery, molecular imaging and vaccine agents. However, their clinical …

The hsa_circ_0039857/miR-338-3p/RAB32 axis promotes the malignant progression of colorectal cancer

P Xu, S Cheng, X Wang, S Jiang, X He, L Tang… - BMC …, 2022 - Springer
Background Colorectal cancer (CRC) is a prevalent malignancy of the gastrointestinal.
Circular RNAs (circRNAs) act as important roles in CRC malignant progression. However …

The complement system: a potential therapeutic target in liver cancer

M Yuan, L Liu, C Wang, Y Zhang, J Zhang - Life, 2022 - mdpi.com
Liver cancer is the sixth most common cancer and the fourth most fatal cancer in the world.
Immunotherapy has already achieved modest results in the treatment of liver cancer …

METTL3-mediated m6A methylation of C1qA regulates the Rituximab resistance of diffuse large B-cell lymphoma cells

J Li, Z Zhu, Y Zhu, J Li, K Li, W Zhong - Cell Death Discovery, 2023 - nature.com
Rituximab has been incorporated into the standard treatment regimen for diffuse large B-cell
lymphoma (DLBCL), and induces the death of tumor cells via complement-dependent …

Cuproptosis-related risk score based on machine learning algorithm predicts prognosis and characterizes tumor microenvironment in head and neck squamous …

M Ye, G Zhang, Y Lu, S Ren, Y Ji - Scientific Reports, 2023 - nature.com
Cuproptosis is a recently discovered type of programmed cell death that shows significant
potential in the diagnosis and treatment of cancer. It has important significance in the …