Arguably the most critical advancement in the elucidation of factors affecting atherogenesis
has been the development of mouse models of atherosclerosis. Among available models …

▪ Abstract Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors
that function as intracellular sensors for sterols and bile acids, respectively. In response to …

Heritable variation in complex traits is generally considered to be conferred by common
DNA sequence polymorphisms. We tested whether rare DNA sequence variants collectively …

Evidence of reduced blood-brain barrier (BBB) integrity preceding other Alzheimer's disease
(AD) pathology provides a strong link between cerebrovascular angiopathy and AD …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

ABCA1, ABCA7, and ABCA4 are members of the ABCA subfamily of ATP-binding cassette
transporters that share extensive sequence and structural similarity. Mutations in ABCA1 …

The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …

Patients with Tangier disease exhibit extremely low plasma HDL concentrations resulting
from mutations in the ATP-binding cassette, sub-family A, member 1 (ABCA1) protein …

A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of
cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol …