▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …

We comprehensively reviewed the published scientific literature on non-steroidal anti-
inflammatory drugs (NSAIDs) and cancer and evaluated results based upon epidemiologic …

Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including
anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX …

Cyclooxygenase‐2 (COX‐2) is an inducible form of the enzyme that catalyses the synthesis
of prostanoids, including prostaglandin E2 (PGE2), a major mediator of inflammation and …

Zerumbone (ZER), a sesquiterpene from the edible plant Zingiber zerumbet Smith, has
recently been found to suppress tumor promoter 12-O-tetradecanoylphorbol-13-acetate …

The relevance of cyclooxygenases (COX)-1 and-2 and their products to inflammation,
thrombosis and gastroprotection are well known. Their importance in the immune response …

Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many
steps of cancer development. Single nucleotide polymorphisms (SNPs) in the COX-2 …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

Elevated tumor cyclooxygenase (COX-2) expression is associated with increased
angiogenesis, tumor invasion, and suppression of host immunity. We have previously shown …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …