This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Here, we review potential determinants of the anticancer efficacy of innate immune peptides
(ACPs) for cancer cells. These determinants include membrane‐based factors, such as …

Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms and are promising candidates to treat infections caused by pathogenic bacteria to …

Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …

In recent years, the number of known peptide natural products that are synthesized via the
ribosomal pathway has rapidly grown. Taking advantage of sequence homology among …

In this text, the small team of expert authors presents the field in a comprehensive and
accessible manner that is well suited for students and junior researchers. The result is a …

Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino
acids. A large number of natural cyclopeptides have been reported to be highly effective …

Abstract Cycloviolacin O2 (CyO2), a cyclotide from Viola odorata (Violaceae) has antitumor
effects and causes cell death by membrane permeabilization. In the breast cancer line, MCF …

Cyclotides are a unique and growing family of backbone cyclized peptides that also contain
a cystine knot motif built from six conserved cysteine residues. This unique circular …

Cyclotides are remarkably stable proteins from plants that have a range of pharmaceutical
and agricultural applications based on both their various bioactivities and their potential for …