Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

▪ Abstract The transforming growth factor β (TGF-β) family of proteins are a set of pleiotropic
secreted signaling molecules with unique and potent immunoregulatory properties. TGF-β1 …

Both antigen-specific and non-specific mechanisms may be involved in the pathogenesis of
oral lichen planus (OLP). Antigen-specific mechanisms in OLP include antigen presentation …

Elimination of CD25+ T cells, which constitute 5-10% of peripheral CD4+ T cells in normal
naive mice, leads to spontaneous development of various autoimmune diseases. These …

AT helper cell type 1–mediated colitis develops in severe combined immunodeficient mice
after transfer of CD45RBhigh CD4+ T cells and can be prevented by cotransfer of the …

We show that a combination of the immunosuppressive drugs, vitamin D3 and
Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into …

Th1-and Th2-type cytokines (termed Th0) have been likely that the dose and route of
immunization of antigen described in human and mouse systems (Sher and Coffmay also be …

Abstract CD4+ T regulatory type 1 (Tr1) cells suppress Ag-specific immune responses in
vitro and in vivo. Although IL-10 is critical for the differentiation of Tr1 cells, the effects of …

CD3-specific antibodies have the unique capacity to restore self-tolerance in established
autoimmunity. They induce long-term remission of overt diabetes in nonobese diabetic …

Regulatory CD25+ CD4+ T cells are considered as important players in T cell homeostasis
and self-tolerance. Here we report that the integrin αEβ7, which recognizes epithelial …