Giardia duodenalis: biology and pathogenesis

RD Adam - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Giardia duodenalis captured the attention of Leeuwenhoek in 1681 while he was examining
his own diarrheal stool, but, ironically, it did not really gain attention as a human pathogen …

Behind the smile: cell biology and disease mechanisms of Giardia species

J Ankarklev, J Jerlström-Hultqvist, E Ringqvist… - Nature Reviews …, 2010 - nature.com
The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when
Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal …

Giardia—from genome to proteome

RCA Thompson, P Monis - Advances in parasitology, 2012 - Elsevier
In this review, the current status of genomic and proteomic research on Giardia is examined
in terms of evolutionary biology, phylogenetic relationships and taxonomy. The review also …

Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate

J Jerlström-Hultqvist, O Franzén, J Ankarklev, F Xu… - BMC genomics, 2010 - Springer
Background Giardia intestinalis is a protozoan parasite that causes diarrhea in a wide range
of mammalian species. To further understand the genetic diversity between the Giardia …

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

G Manning, DS Reiner, T Lauwaet, M Dacre, A Smith… - Genome biology, 2011 - Springer
Background The major human intestinal pathogen Giardia lamblia is a very early branching
eukaryote with a minimal genome of broad evolutionary and biological interest. Results To …

The nucleolus of Giardia and its ribosomal biogenesis

FA Lagunas-Rangel - Parasitology Research, 2023 - Springer
G iardia duodenalis is a protozoan intestinal parasite that causes a significant number of
infections worldwide each year, particularly in low-income and developing countries …

[HTML][HTML] New insights regarding the biology of Giardia lamblia

PG Carranza, HD Lujan - Microbes and infection, 2010 - Elsevier
Giardia lamblia is one of the most common causes of intestinal disease in humans. To adapt
to environments both inside and outside of the host's small intestine, this protozoan parasite …

Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2)

J Müller, P Schildknecht, N Müller - Journal of Antimicrobial …, 2013 - academic.oup.com
Abstract Objectives The protozoan parasite Giardia lamblia causes giardiasis, a persistent
diarrhoea. Nitro drugs such as the nitroimidazole metronidazole and the nitrothiazolide …

Ultrastructural and proteomic evidence for the presence of a putative nucleolus in an Archaeon

PF Islas-Morales, A Cárdenas, MJ Mosqueira… - Frontiers in …, 2023 - frontiersin.org
Nucleoli are subcellular compartments where transcription and maturation of pre-ribosomal
RNAs occur. While the transcription of ribosomal RNAs is common to all living cells, the …

Unusual Cell Structures and Organelles in Giardia intestinalis and Trichomonas vaginalis Are Potential Drug Targets

M Benchimol, AP Gadelha, W de Souza - Microorganisms, 2022 - mdpi.com
This review presents the main cell organelles and structures of two important protist
parasites, Giardia intestinalis, and Trichomonas vaginalis; many are unusual and are not …