Photoaffinity labeling (PAL) using a chemical probe to covalently bind its target in response
to activation by light has become a frequently used tool in drug discovery for identifying new …

Light-controllable tools provide powerful means to manipulate and interrogate brain function
with relatively low invasiveness and high spatiotemporal precision. Although optogenetic …

Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

Allostery is the most direct and efficient way for regulation of biological macromolecule
function, ranging from the control of metabolic mechanisms to signal transduction pathways …

Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

Photopharmacology involving azobenzene or dithienylethene has changed established
methods of studying receptor functions, allowing for increasing the spatiotemporal …

Background Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical
transmission of nerve signals in the central and peripheral nervous system. On the functional …

Photoaffinity labeling (PAL) was used to identify the binding site of chroman-4-one-based
SIRT2-selective inhibitors. The photoactive diazirine 4, a potent SIRT2 inhibitor, was …

Receptors containing α4 and β2 subunits are a major neuronal nicotinic acetylcholine
receptor (nAChR) subtype in the brain. This receptor plays a critical role in nicotine …

For decades, the development of selective compounds has been the main goal for chemists
and biologists involved in drug discovery. However, diverse lines of evidence indicate that …