BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

The heart is the most metabolically active organ in the human body, and cardiac metabolism
has been studied for decades. However, the bulk of studies have focused on animal models …

Aims Studies have linked gut microbiome and heart failure (HF). However, their causal
relationships and potential mediating factors have not been well defined. To investigate the …

Abstract Background and Aims Low birth weight is a common pregnancy complication,
which has been associated with higher risk of cardiometabolic disease in later life. Prior …

The genetic and genomic basis of sex differences in blood pressure (BP) traits remain
unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide …

Background Observational studies have suggested a close association between atrial
fibrillation (AF) and heart failure (HF), yet the causal effect remains uncertain. In this study …

Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause
of morbidity and mortality, yet causal mechanisms remain largely elusive. Here, we perform …

Recent genome-wide association studies have successfully identified associations between
genetic variants and simple cardiac morphological parameters derived from cardiac …

Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain
amino acid (BCAA) catabolism has also been recognized as a metabolic hallmark and …

Several large-scale studies have measured plasma levels of the proteome in individuals
with cardiovascular diseases (CVDs),,,,,–. However, since the majority of such proteins are …