BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse
applications, both in medical treatments and as a staining reagent. In recent years there was …

Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has
found uses in various areas of medicine and biology. At present, MB is the first line of …

Tauopathies such as Alzheimer's disease (AD), frontotemporal lobar degeneration, or
progressive supranuclear palsy constitute a group of brain disorders defined by …

It is the mature gametocytes of Plasmodium that are solely responsible for parasite
transmission from the mammalian host to the mosquito. They are therefore a logical target …

The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down …

Preventing transmission is an important element of malaria control. However, most of the
current available methods to assay for malaria transmission blocking are relatively low …

Introduction Neurofibrillary tangles (NFT) composed of Tau are hallmarks of
neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro …

This paper provides the first review of the memory-enhancing and neuroprotective metabolic
mechanisms of action of methylene blue in vivo. These mechanisms have important …

Background Methylene blue (MB) was the first synthetic antimalarial to be discovered and
was used during the late 19th and early 20th centuries against all types of malaria. MB has …