Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …

Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

Malignant melanoma is considered the most lethal skin cancer if it is not detected and
treated during its early stages. About 10% of melanoma patients report a family history of …

Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

Background: The major factors individually reported to be associated with an increased
frequency of CDKN2A mutations are increased number of patients with melanoma in a …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …

Melanoma, a cancer of the skin, arises from transformed melanocytes. Melanoma has the
highest mutational burden of any cancer partially attributed to UV induced DNA damage …

Background: Germline mutations in the CDKN2A gene, which encodes two proteins
(p16INK4A and p14ARF), are the most common cause of inherited susceptibility to …

GenoMEL, comprising major familial melanoma research groups from North America,
Europe, Asia, and Australia has created the largest familial melanoma sample yet available …